Gluconeogenesis (GNG) always continues.

Gluconeogenesis (GNG) always continues.

Gluconeogenesis (GNG) always continues.

When you wake up in the morning, half of the glucose in your blood may be coming from GNG.

The difference in people with diabetes is that they have lost the ability to close this mechanism at the right time. The reason for this is the decrease or absence of insulin, as in type 1 diabetes, or a poor/insufficient response to insulin, as in type 2 diabetes.

The presence of dietary glucose in healthy people causes insulin secretion, which slows down gluconeogenesis and glycogen rejection.

Many people think that the high blood sugar rate seen in diabetes is since the blood sugar level does not decrease because the cells cannot draw glucose out of the blood to use as a fuel.

Although the number of GLUT4 sensors in people with diabetes does not increase as much against nutritional glucose as in healthy people, it seems that this is not the main cause of hyperglycemia - people with diabetes still have enough of these glucose carrier sensors in most cases.

It seems that the main problem is the continuation of glucose production in the liver.

Normally, the release of glucose from glycogen and gluconeogenesis in the liver is controlled by insulin and glucagon. As glucose increases, insulin increases and glucagon decreases. In response, the liver stops producing more glucose.

One of the main features of diabetes is the loss of this stimulating-response control over glucose production. With this in mind, it would not make sense to recommend nutritional glucose to people with diabetes, as this only adds to the uncontrolled production within the body!

The limitation of nutritional carbohydrates has been used as a treatment for diabetes since the discovery of insulin. It is not a new idea that controlling the glucose level in the blood has positive effects on all factors following this disease, including lipid indicators related to cardiovascular diseases and the frequency of cardiovascular disease.

To improve or eliminate the symptoms of many diabetic patients, all it takes is the limitation of nutritional carbohydrates. Normal glucose control, stable body weight, and normal lipid levels can be achieved, and these benefits remain as long as carbohydrate intake remains low. At this point, the question to be asked is the semantic question of whether the patient can be considered “healed” if they need to continue the diet constantly. At this point, I find it more correct to use the word reversing rather than recovery!


Diabetes is a carbohydrate tolerance-deficiency disease.

While type 1 diabetes is characterized by not being able to produce insülin against carbohydrates, lateral insulin resistance is observed in type 2 diabetes with decay in beta cells in the pancreas. The most prominent symptom of diabetes (and its most contributing feature to its pathology) is high blood sugar, and, surprisingly, the most effective treatment for this is the reduction of nutritional carbohydrates.

Clinical criteria on this subject:

(1) fasting blood sugar,

(2) oral glucose tolerance test that measures the response in the blood to a given glucose dose; and

(3) is the percentage of hemoglobin A1c (HbA1c). It is not difficult to guess what is the best treatment of a disease characterized by a negative reaction to nutritional carbohydrates.

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Sencer Bulut