Honey, molasses, agave, fruit, table sugar (sucrose) and high fructose corn syrup (HFCS). It is a simple ketonic monosaccharide found in many plants and usually attached to glucose to form the disaccharide sucrose. It is one of three dietary monosaccharides with glucose and galactose and is absorbed directly into the blood during digestion.
High fructose consumption causes Metabolic Syndrome due to its unique metabolism and the results are as follows:
- Intracellular ATP depletion
- Uric acid production
- Endothelial dysfunction
- Oxidative stress and
- De novo lipogenesis (Re-FAT formation) (DNL).
Another problem with fructose is that by nature it is never alone; it always binds with glucose and is, therefore, a double problem for the liver. The excessive consumption of fructose and the development of metabolic syndrome (obesity, dyslipidemia, hypertension, insulin resistance, pro-inflammatory status, prothrombotic) may be associated. Rapid metabolism of fructose in the liver and associated decline in hepatic adenosine triphosphate (ATP) levels have been associated with mitochondrial and endothelial dysfunction and changes that will predispose to obesity, diabetes, and hypertension.
Fructose and Liver
Digested carbohydrates are a great stimulant for hepatic de novo lipogenesis (DNL) and are more likely to have a direct share in the development of NAFLD (non-alcoholic liver disease). While every cell in the body can use glucose, fructose can only be metabolized by the liver.
It is a "chronic, dose-dependent liver toxin". And just like alcohol, fructose is metabolized directly into fat, not cellular energy, like glucose.
1- Your liver's fructose metabolism is similar to alcohol, both act as substrates to convert carbs into fat, which supports insulin resistance, dyslipidemia (abnormal levels of blood circulation) and liver fat.
2- Fructose undergoes a Maillard reaction with proteins. This leads to the formation of superoxide free radicals, which can lead to liver inflammation similar to the intermediate metabolite of ethanol, acetaldehyde.
3- Stimulating fructose, directly and indirectly, the hedonic pathway of the brain and it also reacts in parallel with ethanol.
If you give fructose to animals, they lose their ability to control their appetite, eat more and exercise less. Fructose plays a direct role in weight gain.
Losing the ability to control appetite is what it makes into "Leptin Resistance", and then falls into a group called "Metabolic Syndrome", which turns into obesity, liver and other problems.
The liver cannot distinguish whether fructose is from fruits or table sugar. It just has to clear.
Fructose and Blood Sugar
Fructose is metabolized by the liver into fat. Therefore, the fructose part of the fruit sugar will not affect blood sugar, but it will leave the liver under stress. Also, showing that fructose and blood glucose lowers blood sugar by mixing fructose and glucose is nothing but deception.
Everyone knows that blood glucometers do not measure fructose. And if you dilute a glucose solution with fructose, clearly the glucose concentration will be lower.
Arguments Used for Selling Fructose
1- Fructose does not raise blood sugar. However, they never tell you about the harm caused by fructose to the liver and overall health.
2- Fruits are natural, so they are good. The liver does not have a brain or eye. He cannot distinguish between fructose from fruits or table sugar.
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